Google Tech Talks
October 30, 2008
ABSTRACT
In 18 months full human genome sequences will be available under $100 – and in minutes. The $5,000 full human genome was announced to come in 9 months. Is “Big IT” ready for the avalanche of data, to be obtained and processed e.g. while the patient is still on the operating table, to be diagnosed, and how the genomics glitch, that caused a benign or malign tumor, could be compensated for?
Algorithmic approaches are needed to better understand genome regulation, even for the simple reason to deploy most effective data retrieval, data storage and computational means, via both parallel hardware and software, but more importantly for opening entirely new perspectives.
In the 100+ year old Genomics, for over half a Century had us to resign to the fatalistic gloom that we are stuck with any glitches in our inherited genome. Is it true that genomic glitches doom one to “incurable” hereditary diseases?
No longer. Genomics now considers the DNA-RNA-Protein chain not as a thermodynamically closed system, where entropy increases, but as an open system that can be interfered with. There is theoretically sound hope that you are not stuck with your genomic glitches.
After half a Century of sticking to two mistaken axioms of Genomics, the paradigm of recursive genome function must quickly make up for lost time for those (potentially) inflicted with formerly “incurable” diseases. “The Genome baby is left on the doorsteps of Information Technology”.
Doctors sent those inflicted with fleece for “debugging”. Debugging genome information (by Genome Computers) would be much harder without understanding the algorithms that our natural genome computing operates with.
Speaker: Dr. Andras Pellionisz
Ph.D. in Biology
Ph.D. in Computer Engineering
Director of Genome Informatics, Mitrionics, Inc., Los Gatos, California
European Union visiting Professor for Hungary (for “European Inaugural of IPGS”)
Founder of International PostGenetics Society (IPGS,PostModern era of Genetics “beyond Genes”)
Founder of FractoSoft (Software for PostGenetics, Silicon Valley, with Central European outsourcing)
Founder of Helixometry (IP portfolio holding, Silicon Valley)
Inventor and Founder of FractoGene (Fractal approach to DNA)
Chief Software Architect and Chief Intelligence Officer of several Silicon Valley Internet Companies in the dot.com boom
Founder of International Neural Networks Society (INNS)
Founding Editor of Neural Networks (publication organ of INNS)
Section Editor for Neural Networks of The Cerebellum (Springer, New York & Heidelberg)
Professor of Physiology and Biophysics, New York University Medical Center
Visiting Professor of Marburg University, Germany (Humboldt Prize for Senior Distinguished Amercian Scientists)
Visiting Professor of UMR/CNRS, College de France, Paris
Senior Research Council Associate of the National Academy of Science, USA, to NASA
PostDoctoral Fellow, University of Iowa
PostDoctoral Fellow, Stanford University
Tenured Senior Research Fellow of the Hungarian Academy of Sciences
Duration : 0:58:0
[youtube WJMFuc75V_w]
June 26th, 2010 at 8:48 pm
Your response seems …
Your response seems to be a non-sequitur. It does nto appear to an objective reader that Johnny was attempting to set him or herself up as a brilliant paradigm-shifter at all; I do not see how bringing up a legitimate criticism makes you think he/she was. Adoration of Pellionisz, on the other hand, will not erase his tactics.
June 26th, 2010 at 8:48 pm
Young T. Ryan …
Young T. Ryan Gregory launched a career on “Junk DNA” (minimizing that Ohno declared a majority of human DNA “to do nothing”). Now TRG is trying to “fuzz up” his stance. Formerly, TRG bunched up with a Lonely Moron full of junk, who still clings to that silly notion. No longer – TRG also dropped “anonymes”. While trying to salvage his career launched on “junk DNA” TRG is now playing both sides of the fence; thus his recent entries are rather confusing. He is welcome to clarify. – Principals Only
June 26th, 2010 at 8:48 pm
Brilliant people …
Brilliant people are capable of leading historical paradigm shifts or revisions.
Obviously you are not one of them and that precisely is your problem JohnnyBananas802.
Negative criticism of Pellionisz, will not make you measure up.
Do me a favor and keep you suggestions to yourself.
June 26th, 2010 at 8:48 pm
What do you think …
What do you think Einstein would have thought about engaging in historical revisionism to make oneself seem more important and ‘cutting edge’?
I suggest you do a simple lit search on ‘junkDNA’…
June 26th, 2010 at 8:48 pm
I agree. You …
I agree. You should read his forays onto internet discussion boards. He recently claimed, for example, that geneticist T. Ryan Gregory agreed that junkDNA is a myth and referred to one of Gregory’s blog posts dated Sept. 18. Well, the title of that blog post did contain the words “junkDNA” and “myth”, but he was referring to the claim that there is no such thing as junkDNA is a myth. Pellionisz was unable to understand that, and when corrected, simply ignored the guy that pointed it out..
June 26th, 2010 at 8:48 pm
This presentation …
This presentation is eye-opening for those who no longer wish to hide their heads in the sand. The aim of his talk is not to intimidate, but to enlighten and instill hope. Pellionisz single-handedly drags the audience into the future where the merger of genomics and IT will save and improve lives. The revolutionary ideas he presents are often attacked by cynics, but as Albert Einstein once said: “Great spirits have always encountered violent opposition from mediocre minds”
June 26th, 2010 at 8:48 pm
With the affordable …
With the affordable full human DNA sequencing already here (Complete Genomics shown their first full human DNA sequence for $5,000 in the February 5th meeting in Marco Island, FL – and Pacific Biosciences published a “proof of concept” paper in Science for full DNA sequencing in the range of $100 in little over a year from now, we are all heading towards a “Genome Based Economy”. The Churchill Club held a Panel on January 22, 2009 with the title “Personal Genome Computing” – search it in YouTube
June 26th, 2010 at 8:48 pm
Thomas Kuhn, in his …
Thomas Kuhn, in his bestseller book “The Structure of Scientific Revolutions” (1969) said that in a paradigm-shift the old and new definitions are mutually incompatible. Wouter van Ooijen, a young computer scientist, is apparently unaware of the fact that ENCODE (June 14, 2007) called for a “re-thinking of old beliefs” of 100-year old Genetics; including the very definition of what a “Gene” might be. One might recommend viewing a Panel (YouTube “pellionisz”) struggling with the same challenge.
June 26th, 2010 at 8:48 pm
My PR warns against …
My PR warns against anonymous “shitck” name-callers. Great that you second my statement: DNA is an OPEN SYSTEM where genome entropy is not inevitable to escalate. So let’s give hope, not a gloomy mindset that we are stuck with genomic glitches! Interdisciplinary scientists note I focused on DNA – not cells. With energy pumped into it, entropy increases – unless DNA is open to changes by epigenomic interference. Molecular biologists will agree that methylation is #1 mechanism in the limelight.
June 26th, 2010 at 8:48 pm
@33′01”
Slide …
@33′01”
Slide reads:
“”"
As long as DNA>RNA>PROTEIN was a closed system The Second Law of Thermodynamics applied – an increase of enthropy was inevitable
“”"
FYO: nobody who is somebody ever said that a cell, DNA, replication, transcription or translation is a closed system, much less so Watson, Crick or Ohno. You need energy (ATP)
to run any of these. Methylation or not it is an OPEN SYSTEM.
June 26th, 2010 at 8:48 pm
Waste of time. This …
Waste of time. This guy shitck is to dazzle biologist with comp-math-phis terms (fractal, recurency, FPGA) and comp guy with bio terms (Purkinje cells etc.). It does not work fr a bioinformatician.
I quited soon after statement that without DNA methylation we would have problem with thermodynamics of DNA. Wow, simply wow! So Second law is so specific? Using energy DNA repair is not good enough?
Bombastic names (”circle of life” anyone?), prosecution complex + penchant for kicking corpses.
June 26th, 2010 at 8:48 pm
This is a piece of …
This is a piece of blithering buffoonery from someone who doesn’t begin to understand Pellionisz, much less the import of his ideas.
June 26th, 2010 at 8:48 pm
This sounds good, …
This sounds good, but once you actually analyse what he says it is often total nonsense. A mix of words from various sciences, used with total disregard for their definitions.
June 26th, 2010 at 8:48 pm
This is an …
This is an interesting video.
It looks like Terrence McKenna had some promising ideas about genetic evolution after all…
June 26th, 2010 at 8:48 pm
sarah ann boswell
sarah ann boswell
June 26th, 2010 at 8:48 pm
Wow, 18 months?! …
Wow, 18 months?! Finally we’ll know the origins and migration paths of all nations, this could be explosive in Eastern Europe. Hungarians tried to find their ancestral home for centuries. This will become political very fast.